Found genes for high cholesterol in the blood

Scientists from ScienceDaily — (September 15, 2010) of the Southwest Foundation for biomedical research (SFBR) in San Antonio found a gene to accumulate the high in the blood due to a bad high cholesterol diet.

Researchers investigated a laboratory, the tribes of opossums in SFBR that "bad" cholesterol has low density lipoprotein (LDL), if a diet fed cholesterol lower standard, but extremely high levels of LDL cholesterol, if sangre.estos fed high respond to possums, identify a diet much in normal cholesterol genes and the underlying mechanisms to control the response to the dietary cholesterol be used.

"This research improves our understanding of the metabolism of cholesterol and can provide information about, why some people high bad blood cholesterol, while others don't have if diet rich in cholesterol," said John l. VandeBerg, pH.d, Chief Scientific Officer and senior role SFBR author. published in the October issue of the journal of lipid research, the work was financed health, Robert j. Kleberg, Jr. and Helen C. Kleberg Foundation by national offices.

The study involved analysis of lipids or fats in the blood and bile to find found differences in cholesterol metabolites, mutations and determine the impact of each mutation analysis genéticos.Esto led to the discovery that the ABCB4 that encodes a protein known to facilitate fats from the liver bile excretion of cholesterol in the body to transport high response.Found commissioned the ABCB4 gene defective computers the excretion of cholesterol, protein, the bad blood to collect when a diet that consume high cholesterol cholesterol caused damage genes candidates of interest.

"This is the first report show that the ABCB4 has a role in the control of blood in response to dietary cholesterol cholesterol in an animal model", said VandeBerg.

"The next step is to determine whether each ABCB4 mutations have effect on the levels of LDL cholesterol in humans to consume a diet of high cholesterol.""If we soon can identify in the lives of people who will be negatively affected by high cholesterol consumption we encourage parents and get individually tailored advice makes eating habits to protect the cardiovascular diseases", says VandeBerg.

Co-authors in the paper were Jeannie Chan pH.d, Michael C. Mahaney, pH.d Rampratap S. Kushwaha pH.d.and Jane f. VandeBerg SFBR genetics Department.

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